Elucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels.

Elucidating the molecular basis of action of a classical drug: Guanidine compounds as inhibitors of voltage-gated potassium channels

Design of Novel Drugs (P3TZ, H2P3TZ, M2P3TZ, H4P3TZ and M4P3TZ) Based on Zonisamide for Autism Treatment by Binding to Potassium Voltage-gated Channel Subfamily D Member 2 (Kv4.2)

The present research article relates to the discovery of the novel drugs based on Zonisamide to treatment of autism disease. In first step, the electronic properties, reactivity and stability of the said compound are discussed. To attain these properties, the said molecular structure is optimized using B3LYP/6-311++G(d,p) level of theory at room temperature. The frontier molecular orbitals (FMO...

Influence of the multidrug transporter inhibitors on the activity of Kv1.3 voltage-gated potassium channels.

Using the whole-cell patch-clamp technique, the influence of selected multidrug resistance modulators, both plant-derived compounds and derivatives on the activity of voltage-gated potassium channels Kv1.3 was investigated. Twelve compounds with phenolic and terpenic structures were tested: the stilbenes piceatannol (1) and its tetramethoxy (2) and tetracetoxy (3) derivatives, the flavonoids na...

Antiepileptic Drug Targets: An Update on Ion Channels

Different mechanisms of action have been proposed to explain the effects of antiepi‐ leptic drugs (AEDs) including modulation of voltage‐dependent sodium calcium and potassium channels, enhancement of γ‐aminobutyric acid (GABA)‐mediated neuronal inhibition, and reduction in glutamate‐mediated excitatory transmission. Recent advances in understanding the physiology of ion channels and genetics b...

The Blocking Activity of Different Toxins against Potassium Channels Kv3.4 in RLE Cells

Background: K+ channel toxins are essential tools for the first purifications, analysis of subunit structures and brain localization of voltage-gated K+ (Kv) channels. The effects of a lot of toxins on Kv are not fully known. Methods: Using whole-cell patch clamping technique the action of a series of toxins on Kv3.4 current in rat liver cells with expressed Kv3.4 channels (RLE) cloned cells wa...